منابع مشابه
Towards global polio eradication: Australia's commitment to the global eradication of poliovirus by 2005.
• Do you have or have you ever stored samples of poliovirus? • Do you have or have you ever stored samples that might potentially harbour such virus (eg. faecal or throat swab samples)? If the answer is yes to either of these questions, the stores of poliovirus and potentially infectious materials should be included on a national inventory currently being compiled by the Commonwealth Department...
متن کاملEradication of poliovirus: fighting fire with fire.
Endemic wild polioviruses have been eliminated from most of the world, and the number of human paralytic cases has been reduced by .99%, from an estimated annual incidence of .500,000 cases to ,2000 cases [1–3]. Circulating wild polioviruses remain endemic in only 2 major locations, Nigeria and a zone extending from northern India west to Pakistan and Afghanistan [1–3]. Furthermore, wild-type 2...
متن کاملPolio eradication. Efficacy of inactivated poliovirus vaccine in India.
Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV in boosting mucosal immunity. Participants received IPV, bivalent 1 and 3 oral poliovirus vaccine (bOPV), or no vaccine. A bOPV challenge was administered 4 weeks later, and excretion was assessed 3, 7, and 14 days later. Nine hundred and ...
متن کاملFeasibility of quantitative environmental surveillance in poliovirus eradication strategies.
The progress of the Global Polio Eradication Initiative is monitored by acute flaccid paralysis (AFP) surveillance supplemented with environmental surveillance in selected areas. To assess the sensitivity of environmental surveillance, stools from (re)vaccinated elderly persons with a low seroprevalence and from wastewater were concurrently collected and analyzed in the Netherlands over a prolo...
متن کاملWhat role for inactivated poliovirus vaccine in the eradication endgame?
The 15-decade drive to control and eradicate polio through immunization [1] has benefited from the availability of 2 excellent vaccines, the inactivated poliovirus vaccine (IPV) of Salk and colleagues, licensed in 1955, and the live attenuated oral poliovirus vaccine (OPV) of Sabin, licensed in 1961. The 2 vaccines have complementary advantages, and both have played—and continue to play—importa...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2018
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-018-0228-y